Ana P. Francisco, Eduarda Mendes*, Ana R. Santos and Maria J. Perry Pages 1623 - 1642 ( 20 )
Triazenes are a very useful and diverse class of compounds that have been studied for their potential in the treatment of many tumors including brain tumor, leukemia and melanoma. Novel compounds of this class continue to be developed as either anticancer compounds or even with other therapeutic applications. This review focused on several types of triazenes from the simplest ones like 1,3-dialkyl-3-acyltriazenes to the more complex ones like combi-triazenes with an emphasis on how triazenes have been developed as effective antitumor agents.
Triazenes, alkylating agents, anticancer activity, prodrugs, aryltriazenes, combi-triazenes, hybrid molecules.
iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Lisbon