Maryam Iman, Hamed Shafaroodi, Asghar Davood, Masoud Abedini, Pouyan Pishva, Mehrnoush Taherkhani, Ahmad Reza Dehpour and Abbas Shafiee Pages 5760 - 5766 ( 7 )
Phthalimide and hydrazine pharmacophores have been demonstrated to be inhibitors of cyclooxygenases (COX) and lipoxygenases (LOX) and to possess a marked analgesic and anti-inflammatory activity. A new group of hybrid analogs of phthalimide and hydrazine (2-(arylmethylideneamino) isoindolines), possessing a variety of substituents (OMe, OH, NO2, Cl, and F) at different positions of the aryl ring, were synthesized and their analgesic and anti-inflammatory effects were evaluated. In vivo screening showed that all the analogs possessed analgesic and anti-inflammatory activity and compounds 10g, 10h and 10e were the most potent as analgesic and compounds 10b, 10c and 10i were the most potent as anti-inflammatory agents.
Analgesic, anti-inflammatory, hydrazone, isoindoline, phthalimide.
, , Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, 19419, Iran.