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The Role of Chemokines, Cytokines and Adhesion Molecules in Stem Cell Trafficking and Homing

[ Vol. 17 , Issue. 30 ]

Author(s):

Y. Cui and P. Madeddu   Pages 3271 - 3279 ( 9 )

Abstract:


Although definition and mechanistic understanding of pro-angiogenic progenitor cells remains unsatisfactory, general agreement highlights their role in regenerative process following tissue injury and ischemia. Furthermore, stem-cell based therapy represents a hot topic of cardiovascular medicine. Recent studies provide new insights on the signalling pathways that modulate stem/progenitor cell mobilization from bone marrow, homing to ischemic area and participation in vascular remodelling and tissue healing. This review focuses on current knowledge and emerging concepts on stem cell/progenitor cell trafficking in relation to changes in surrounding environment and epigenetic modifications caused by risk factors and comorbidities.

Keywords:

Stem cells, cardiovascular disease, ischemia, homing, signalling, repair, endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), chemokine, proteases

Affiliation:

Chair of Experimental Cardiovascular Medicine University of Bristol Bristol Royal Infirmary-level 7 Upper Maudlin St, Bristol BS2 8HW, United Kingdom.



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