A Novel Cobalt(II) Coordination Complex Constructed from H₂Pyri and 4,4′-Bipy: Synthesis, Characterization and Bioactivity

Author(s):

Enjun Gao, Fuchen Zhao, Mingchang Zhu and Meilin Wang   Pages 783 - 792 ( 10 )

Abstract:

The new complex of {[Co(4,4′-Bipy)(H₂O)₄]·(Pyri)·3H₂O}_n (4,4′-Bipy = 4,4′-bipyridyl, H₂Pyri = 3,5- Pyridinedicarboxylic acid) was synthesized and characterized by IR, element analysis and X-ray single-crystal diffraction. The binding of the complex with extracted HeLa cells DNA was investigated by UV and fluorescence spectrum. Gel electrophoresis assay demonstrated the ability of the complex cleaving the extracted HC-DNA. The complex exhibited a higher cytotoxicity against tumor cells in vitro. Furthermore, the apoptotic tests indicated the complex had an apoptotic effect on HeLa cells.

Keywords:

apoptosis, Cobalt(II) complex, cytotoxicity, gel electrophoresis.

Affiliation:

Department of Coordination Chemistry, Shenyang University of Chemical Technology, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemical, Shenyang 110142, China.

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