Jingna Su, Xuyuan Yin, Xiuxia Zhou, Wenyi Wei and Zhiwei Wang Pages 1311 - 1317 ( 7 )
Epithelial to mesenchymal transition (EMT) has been unraveled to regulate the tumor invasion and metastasis processes. In this review, in order to better understand the regulatory mechanisms of EMT, we describe that F-box pr oteins could be critically involved in regulating the EMT process in human cancers. Specifically, we discuss how th ese F-box proteins directly control the stability of EMT regulators such as E-cadherin, β-catenin, Twist, Slug, Snail and ZEB. Moreover, we summary mechanistically how the F-box proteins govern EMT progression through regulation of EMT inducers including Notch, NF-κB, Akt, Hedgehog, mTOR, and HIF-1α. Therefore, targeting these F-box proteins could be useful for treating human cancers.
Cancer, degradation, E3 ligases, EMT, ubiquitin.
, , , , Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215.