K. Kee Suat and Seetharama D.S. Jois Pages 1209 - 1224 ( 16 )
Peptides and proteins are essential to many biological processes. The interaction between the peptide ligands and their receptor targets commonly involves β-turn structures. Yet poor bioavailability and unfavorable pharmacokinetics significantly compromise the use of peptides as drugs. Thus, there has been a great deal of interest in the design of peptidomimetics (modified peptides) as therapeutic agents by mimicking β-turn structures. This review highlights the importance of β-turn in the design of various peptidomimetics for many diseases. This review also outlines several β-turn mimicking strategies and its application in the design of potent peptide analogues. β-turn mimetics often tend to be more rigid in positioning the critically important amino acid residues and thus optimize the surface conformation for productive interaction with the receptors.
proteins, peptidomimetics, amino acid, pharmacokinetics, melanocyte-stimulating hormone, bradykinin, lutenizing, circular dichroism(cd)
Department of Pharmacy, 18 Science drive 4,National University of Singapore,Singapore 117543.