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The Therapeutic Role of Taurine in Ischaemia-Reperfusion Injury

[ Vol. 10 , Issue. 19 ]

Author(s):

R. Kingston, C. J. Kelly and P. Murray   Pages 2401 - 2410 ( 10 )

Abstract:


As a non-toxic endogenous antioxidant, the semi-essential amino acid taurine is a potential attenuator of oxidative damage such as that produced by ischaemia-reperfusion injury. Ischaemia-reperfusion injury is a well established if paradoxical phenomenon whereby ischaemic tissue, doomed to necrosis if it is not reperfused, is actually further damaged by oxidative attack when perfusion is restored. This paper is a review of the literature concerning therapeutic strategies in ischaemia-reperfusion injury, including nonpharmacological and pharmacological interventions. There is consistent experimental evidence of an important role of taurine in ischaemia-reperfusion injury, with a clinical role emerging in human trials of taurine administered prior to coronary artery bypass grafting and heart valve surgery.

Keywords:

antioxidants, ischaemia-reperfusion injury, lipid peroxidation, oxidative stress, reperfusion, taurine

Affiliation:

38 Bru Na Mara, FortLorenzo, Salthill, Galway, Ireland



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