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Small Molecule PET-Radiopharmaceuticals

[ Vol. 20 , Issue. 14 ]

Author(s):

Philip H. Elsinga and Rudi A.J.O. Dierckx   Pages 2268 - 2274 ( 7 )

Abstract:


This review describes several aspects required for the development of small molecule PET-tracers. Design and selection criteria are important to consider before starting to develop novel PET-tracers. Principles and latest trends in 11C and 18F-radiochemistry are summarized. In addition an update of some new developments in regulatory aspects is supplied.

Keywords:

PET, small molecules, radiochemistry, preclinical evaluation, carbon-11, fluorine-18.

Affiliation:

, University Medical Center Groningen, University of Groningen, the Netherlands and Ghent University, Belgium.



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