X. Zhang, H. Fang, J. Zhang, Y. Yuan and W. Xu Pages 5011 - 5021 ( 11 )
APN is an important zinc dependent metallo-exopeptidase, which can degrade the extracellular matrix, and plays an important role in tumor invasion, metastasis and angiogenesis. it has been considered as a suitable target for anti-cancer drug design. Recently, research of structure-based APN inhibitors is becoming an interesting field, and many APN inhibitors have been reported. Here we review a series of APN inhibitors and the recent progress in this field.
Aminopeptidase N,rational drug design,inhibitors,peptidomimetics,anti-tumor,structure activity relationship
, , , , Department of Medicinal Chemistry, School of Pharmaceutical Sciences, ShanDong University, 44, West Wenhua Road, 250012, Ji'nan, ShanDong, P.R. China.