W. Li, L. Du and M. Li Pages 4923 - 4932 ( 10 )
Since the subtypes of α1-adrenergic receptor have been thoroughly determined, to date medicinal chemists raise their deliberation on how to conceive selective α1-adrenergic receptor antagonist with the minimal side effects. It needs to be well recognized that natural products can exist as a significant source of drug leads, thus portraying a consequential capacity in drug design and development. The current review article would like to present a comprehensive survey on natural products, mainly including alkaloids and flavonoids, which exhibit α1-adrenergic receptor antagonistic activities.
α1-adrenergic receptor,antagonist,natural products,alkaloids,flavonoids,homologous GPCRs,vasodilatation,transmembrane domains,G proteins,pharmacological properties
, , Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, Shandong 250012, China.