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A general approach on the surfactants use and their properties in drug delivery systems

Author(s):

Mysrayn Yargo de Freitas Araújo Reis, Renaly Ivyna de Araújo Rêgo, Beatriz Patrício Rocha, Gabryella Garcia Guedes, Ízola Morais de Medeiros Ramalho, Airlla Laana de Medeiros Cavalcanti, Geovani Pereira Guimarães and Bolívar Damasceno*  

Abstract:


Surfactants are amphiphilic molecules of great interest in the pharmaceutical field due to their use in combination with other adjuvants to solubilize poor soluble drugs, improve their dissolution profile, promote permeation, increase drug delivery systems stabilization, among other characteristics. Literature shows that surfactants are included in several pharmaceutical forms composition: tablets, solid dispersions, emulsions, microemulsions, nanoemulsions, liposomes, and niosomes. This review aims to elucidate the different classes of surfactants based on their charges (cationic, anionic, nonionic, zwitterionic, and dimeric), the micelles formation process, and how surfactants molecules geometry can affect this phenomenon. Moreover, current studies regarding the benefits of surfactants in the development of formulations are presented. Finally, a discussion on how charges and chain length of surfactants can interact with the stratum corneum epithelial cells leading to increased permeation or skin irritability is reported.

Keywords:

Amphiphilic molecules, Critical Micelle Concentration, Hydrophile-Lipophile Balance, Micelles, Skin Permeation Mechanism, Pharmaceutical technology.

Affiliation:

Graduate Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grnde, Graduate Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grnde, Graduate Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grnde, Department of Pharmacy, Laboratory of Development and Characterization of Pharmaceutical Products, State University of Paraíba, Campina Grande, Graduate Program in Health Science, Federal University of Rio Grande do Norte, Natal, RN, Department of Pharmacy, Laboratory of Development and Characterization of Pharmaceutical Products, State University of Paraíba, Campina Grande, Department of Pharmacy, Laboratory of Development and Characterization of Pharmaceutical Products, State University of Paraíba, Campina Grande, Graduate Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grnde



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