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Diabetes and COVID-19; a Review of Possible Mechanisms

[ Vol. 27 , Issue. 21 ]


Reyhaneh Moradi-Marjaneh, Fereshteh Asgharzadeh, Elnaz Khordad and Mahdi Moradi Marjaneh*   Pages 2522 - 2527 ( 6 )


Coronavirus disease 2019 (SARS-CoV-2) (COVID-19) has recently raised worldwide public health concerns. The available data on COVID-19 in patients with diabetes is limited but generally indicate that there is an increased risk of developing COVID-19 infection in diabetic patients, which ultimately impacts the overall patient’s survival. Various aspects might be involved; however, the exact mechanisms and interrelationships between diabetes and the novel COVID-19 have not yet been fully elucidated. This review summarizes the possible mechanisms by which present diabetes predispose individuals to COVID-19 infection, modulates the hostviral interactions and increases the risk of mortality. We hope this review can provide beneficial information for further studies and contribute to improved disease management of diabetic patients with COVID-19.


Diabetes, COVID-19, mechanism, risk factor, prognosis, review, SARS-CoV-2.


Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London

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