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Furanodiene: A Novel, Potent, and Multitarget Cancer-fighting Terpenoid

[ Vol. 27 , Issue. 22 ]

Author(s):

Rabia Batool, Azhar Rasul*, Ghulam Hussain, Muhammad Ajmal Shah*, Bushra Nageen, Iqra Sarfraz, Muhammad Kashif Zahoor, Ammara Riaz, Aiza Ajaz and ┼×evki Adem   Pages 2628 - 2634 ( 7 )

Abstract:


Natural products have served as a limitless reservoir of bioactive scaffolds for drug discovery against several disorders. Furanodiene is a bioactive natural product isolated from several plants of genus Curcuma. Its therapeutic potential against cancer, inflammation, and angiogenesis has been well-documented. The current review is an update about the natural sources and anti-cancer action mechanism of furanodiene. Furanodiene exerts its anti-cancer effects via induction of apoptosis in several cancer types by modulating MAPKs/ERK, NF-κB, and Akt pathways. Furanodiene has been systematically studied for its anti-cancer potential. However, pharmacokinetics, pharmacodynamics, pre-clinical and clinical studies still needed to be conducted to completely validate the potential of furanodiene for the treatment of cancer.

Keywords:

Furanodiene, natural compound, terpenoid, sesquiterpene, anti-cancer, antioxidant, Curcuma.

Affiliation:

Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000, Neurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University Faisalabad, 38000, Department of Pharmacognosy, Faculty of Life Sciences, Government College University Faisalabad, 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000, Department of Chemistry, Faculty of Science, Cankiri Karatekin University, 18100 Cankiri



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