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Emerging Therapeutic Approaches to COVID-19

Author(s):

Indrakant Kumar Singh, Pratibha Kumari, Pooja Mittal, Amit Kumar, Bharti Singal, Gulam Mustafa Hasan, Rajiv Aggarwal, Mohammad Amjad Kamal, Archana Singh* and Md. Imtaiyaz Hassan*   Pages 1 - 19 ( 19 )

Abstract:


Coronavirus diseases (COVID-19) is caused by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), which is a positive single-stranded RNA virus having a large genome ~30 kb. SARS-CoV-2 is zoonotic and highly contagious, causing severe pneumonia-like symptoms. The efficacy of the different potential drug and drug candidates against COVID-19 has been investigated which are under various stages of clinical trials. The drugs effective against SARS, and Middle east respiratory syndrome (MERS), have been proposed to have a high potential for the treatment of COVID-19. Here, we selected plant-based materials implicated in the prevention and therapy of COVID-19. The vaccine has shown impressive results in producing antibodies against SARS-CoV2 and has been evaluated for safety, tolerance, and preliminary immunogenicity. Similarly, DNA/RNA-based therapy shown high clinical significance. The plant produces secondary metabolites in response to viral infection to protect them. Many nanomaterials produced by carbohydrates and lipids been exploited for their in-vitro and in-vivo delivery of antiviral therapeutics. Different classes of secondary metabolites have a different mechanism to counter virus attacks. While some natural medicines in the form of vitamins, minerals, herbs, and other nutrients help to enhance immunity, such measures should not replace social distancing, quarantining special care to protect from COVID-19. The standards of reporting were in accordance with the PRISMA guidelines.

Keywords:

COVID-19, SARS-CoV-2, RNA-dependent RNA polymerase, Cytokine storm, Herbal medicine, Vaccine

Affiliation:

Department of Zoology, Deshbandhu College, University of Delhi, New Delhi-110019, Department of Chemistry, Deshbandhu College, University of Delhi, New Delhi-110019, Department of Zoology, Deshbandhu College, University of Delhi, New Delhi-110019, Department of Botany, Hansraj College, University of Delhi, Delhi-110007, School of Biological Sciences, Nanyang Technological University, Singapore- 637551, Department of Biochemistry, College of Medicine, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj – 11942, Department of Mathematics, Deshbandhu College, University of Delhi, New Delhi-110019, King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Department of Botany, Hansraj College, University of Delhi, Delhi-110007, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025



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