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A Clinical Review of COVID-19; Pathogenesis, Diagnosis, and Management

Author(s):

Hussien Ahmed*, Ahmed Sayed, Malak Munir, Mostafa H. Elberry, Ibrahim M Sayed, Mohammed Amjad Kamal, Ahmed Negida, Mahmoud Ahmed Ebada and Eshak I. Bahbah*   Pages 1 - 13 ( 13 )

Abstract:


Severe acute respiratory syndrome-coronavirus (SARS-CoV-2, or COVID-19 virus) is a worldwide pandemic pathogen infecting 210 territories. It belongs to the family coronaviriadae and the order Nidovirales. The SARS-CoV-2 virus is a positive-sense single-stranded RNA enveloped virus that includes spike proteins projecting from the envelope. The spike (S) protein interacts with the human angiotensin-converting enzyme 2 (ACE2) receptor, which plays a role in the viral entry into the cell. The SARS-CoV-2 virus is zoonotic, the wet animal market where live animals are sold is expected to be the source of infection. It is the third zoonotic coronavirus, after SARS-CoV and MERS-CoV. Transmission of the virus among humans is confirmed by direct contact, droplet infection, fecal-oral, and blood transmission. The symptoms of COVID 19 include fever, dry cough, headache, and difficulty of breathing. COVID 19 complications, including the development of acute respiratory distress syndrome (ARDS), acute organ injury, secondary infection, and shock, are common in immunocompromised and elderly patients. Up till now, there is no established treatment for COVID-19, and supportive measures including mechanical ventilation and the use of nonspecific anti-viral therapies such as Remdesevir, Liponavir, and chloroquine are currently applied on the severe cases. Also, until now, there is no approved vaccine for COVID-19. In the review, we gave an update on the SARS-COV2 virus, focusing on the epidemiology, pathogenesis, clinical presentations, treatment options, and preventive measures associated with COVI-19 cases.

Keywords:

COVID-19, Coronavirus, SARS-COV2, Pandemic, Pathogenesis, Diagnosis, and Management

Affiliation:

Clinical Research Management Program, Edson College, Arizona State University, Faculty of Medicine, Ain Shams University, Cairo, Faculty of Medicine, Ain Shams University, Cairo, Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, School of Medicine, Zagazig University, Sharkia, School of Medicine, Zagazig University, Sharkia, School of Medicine, Al-Azhar University, Damietta



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