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Neuroprotective Effects of Ellagic Acid in Alzheimer's Disease: Focus on Underlying Molecular Mechanisms of Therapeutic Potential

Author(s):

Nimra Javaid, Muhammad Ajmal Shah*, Azhar Rasul, Zunera Chauhdary, Uzma Saleem, Haroon Khan, Nazir Ahmed, Md. Sahab Uddin, Bijo Mathew, Tapan Behl and Renald Blundell   Pages 1 - 11 ( 11 )

Abstract:


Neurodegeneration is a multifactorial process involved the different cytotoxic pathways that lead towards neuronal cell death. Alzheimer’s disease (AD) is a persistent neurodegenerative disorder that normally has a steady onset yet later on it worsens. The documented evidence of AD neuropathology manifested the neuro-inflammation, increased reactive oxygen, nitrogen species and decreased antioxidant protective process; mitochondrial dysfunction as well as increased level of acetylcholinesterase activity. Moreover, enhanced action of proteins leads towards neural apoptosis which have a vital role in the degeneration of neurons. The inability of commercial therapeutic options to treat AD with targeting single mechanism leads the attraction towards organic drugs. Ellagic acid is a dimer of gallic acid, latest studies expressed that ellagic acid can initiate the numerous cell signaling transmission and decrease the progression of disorders, involved in the degeneration of neurons. The influential property of ellagic acid to protect the neurons in neurodegenerative disorders is due to its antioxidant effect, iron chelating and mitochondrial protective effect. The main goal of this review is to critically analyze the molecular mode of action of ellagic acid against neurodegeneration.

Keywords:

Ellagic acid, Alzheimer's disease, Antioxidant, Acetylcholinesterase, Mitochondrial dysfunction, Neurodegeneration, Cell signaling

Affiliation:

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Department of Pharmacy, Abdul Wali Khan University, Mardan, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Department of Pharmacy, Southeast University, Dhaka, Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad, Chitkara College of Pharmacy, Chitkara University, Punjab, Department of Physiology and Biochemistry, University of Malta, Msida, MSD2080



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