Arun Kumar and Arun Nanda* Pages 1 - 9 ( 9 )
Low aqueous solubility and poor bioavailability are the major hurdles during drug development for the oral route. A large number of the newly discovered drug molecules fall under BCS II class and have solubility related issues and hence poses low oral bioavailability, which in turn render them as non-suitable candidates for further development. A multitude of solubility enhancement approaches are available, notable among them are salt formation, solid dispersions, inclusion complexes, cocrystallization, nanonization etc. Cocrystallization and Nanonization are among the most widely used approaches in the pharmaceutical field that offer multiple enhancements to the active pharmaceutical ingredients. This review endeavours to cover the recent work, important finding, advantages offered by nano sized cocrystals and their future aspects and challenges in the implementation of this newer approach in pharmaceutical research and development.
Cocrystals, Nanocrystals, Nanotechnology, Cocrystallization, Nanonization, Nano medicine
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak (Haryana), Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak (Haryana)