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Potential Prognostic, Diagnostic and Therapeutic Markers for In-stent Reocclusion in Advanced Age Patients After Coronary Stenting

[ Vol. 24 , Issue. 28 ]

Author(s):

Xia Li*, Fenglin Zhang, Hualan Zhou, Youdong Hu, Xiang Fang, Dianxuan Guo and Ying Chen   Pages 3359 - 3365 ( 7 )

Abstract:


Background: Oxidative stress and inflammatory response played important roles in advanced atherosclerosis. We tried to confirm clinical diagnostic significance of the assessments of oxidative stress and inflammatory response status with in-stent reocclusion in 283 advanced age patients (80~90 years) after coronary stenting.

Methods: We analyzed levels of circulating superoxide dismutase 3 (SOD3), nitric oxide (NO), endothelial nitric oxide synthase (eNOS), malondialdehyde (MDA), acrolein(ACR), and paraoxonase-1 (PON-1)in advanced age patients with in-stent restenosis and reocclusion after coronary stenting.

Results: Levels of SOD3, eNOS, NO and PON-1 were lowered (P<0.001) and levels of MDA and ACR were increased (P<0.001).

Conclusion: The assessments of the biomarkers of oxidative stress and inflammatory response (levels of MDA and ACR) and anti-oxidant biomarkers (levels of eNOS, NO, SOD3 and PON-1) could be considered as potential prognostic and diagnostic indicators of in-stent reocclusion in advanced age patients after coronary stenting.

Keywords:

Coronary heart disease, coronary stenting, coronary artery, in-stent reocclusion, atherosclerosis, oxidative stress.

Affiliation:

Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an



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