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Pharmacokinetic and Pharmacodynamic Features of Nanoemulsion Following Oral, Intravenous, Topical and Nasal Route

[ Vol. 23 , Issue. 17 ]

Author(s):

Hira Choudhury*, Bapi Gorain, Bappaditya Chatterjee, Uttam K. Mandal, Pinaki Sengupta and Rakesh K. Tekade*   Pages 2504 - 2531 ( 28 )

Abstract:


Background: Most of the active pharmaceutical ingredients discovered recently in pharmaceutical field exhibits poor aqueous solubility that pose major problem in their oral administration. The oral administration of these drugs gets further complicated due to their short bioavailability, inconsistent absorption and inter/intra subject variability.

Methods: Pharmaceutical emulsion holds a significant place as a primary choice of oral drug delivery system for lipophilic drugs used in pediatric and geriatric patients. Pharmacokinetic studies on nanoemulsion mediated drugs delivery approach indicates practical feasibility in regards to their clinical translation and commercialization.

Results: This review article is to provide an updated understanding on pharmacokinetic and pharmacodynamic features of nanoemulsion delivered via oral, intravenous, topical and nasal route.

Conclusion: The article is of huge interest to formulation scientists working on range of lipophilic drug molecules intended to be administered through oral, intravenous, topical and nasal routes for vivid medical benefits.

Keywords:

Hydrophobicity, oral delivery, pharmacokinetics, pharmacodynamics, routes of administration, carbon nanotubes.

Affiliation:

International Medical University, Department of Pharmaceutical Technology, Kuala Lumpur, 57000, Faculty of Pharmacy, Lincoln University College, Kuala Lumpur, Kulliyyah of Pharmacy, International Islamic University Malaysia, Pahang, Kulliyyah of Pharmacy, International Islamic University Malaysia, Pahang, Kulliyyah of Pharmacy, International Islamic University Malaysia, Pahang, National Institute of Pharmaceutical Education and Research (NIPER) – Ahmedabad, Department of Pharmaceutics, Opposite Air Force Station Palaj-Basan Road, Gandhinagar, Gujarat 382355



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