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Understanding the Interaction Between Human Serum Albumin and Anti-Bacterial/ Anti-Cancer Compounds

[ Vol. 21 , Issue. 14 ]

Author(s):

Md Tabish Rehman and Asad U. Khan   Pages 1785 - 1799 ( 15 )

Abstract:


Human serum albumin (HSA) is the most important carrier of exogenous and endogenous molecules in human plasma. Understanding and characterizing the interaction of drugs with HSA has attracted enormous research interests from decades. The nature and magnitude of these bindings have direct consequence on drug delivery, pharmacokinetics, pharmacodynamics, therapeutic efficacy and drug designing. An overview of HSA and antibacterial/ anti-cancer ligands interaction is the need of the hour as these drugs together constitute more than half of the total drug consumption in the world. In this review, the information on the number of binding sites, binding strength, the nature of binding interactions and the location of binding sites of such drugs on the HSA are summarised. The effect of such drugs on the overall conformation, stability and function of HSA is also reviewed. This review will help to gain useful insights into the significance of the binding of anti-bacterial and anti-cancer drugs with plasma protein and the effect of binding on its overall distribution and pharmacological activities.

Keywords:

Human serum albumin, anti-bacterial drugs, anti-cancer drugs, protein-drug interaction.

Affiliation:

Medical Microbiology and Molecular Biology Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, UP, India-202002.



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