Submit Manuscript  

Article Details


Review: Modifications of Human Serum Albumin and their Binding Effect

[ Vol. 21 , Issue. 14 ]

Author(s):

Philbert Lee and Xiaoyang Wu   Pages 1862 - 1865 ( 4 )

Abstract:


Human serum albumin (HSA) regulates the transport and availability of numerous chemical compounds and molecules in the blood vascular system. While previous HSA research has found that HSA interacts with specific varieties of ligands, new research efforts aim to expand HSA’s ability to interact with more different drugs in order to improve the delivery of various pharmacological drugs. This review will cover fatty acid chain and posttranslational modifications of HSA that potentially modulate how HSA interacts with various pharmacological drugs, including glycation, cysteinylation, S-nitrosylation, S-transnitrosation and S-guanylation.

Keywords:

Human serum albumin.

Affiliation:

929 E. 57 St., Chicago, Illinois USA, Zip code: 60637.



Read Full-Text article