Xingtao Zhao, Ying Deng, Xinyan Xue, Li Liao, Mengting Zhou, Cheng Peng and Yunxia Li* Pages 727 - 742 ( 16 )
Background: Quercetin is the main dietary flavonoid with a wide range of pharmacological activities. However, the poor gastrointestinal absorption and low bioavailability of quercetin curtail its clinical applications.
Methods: We performed a systematic research on the quercetin drug delivery system in PubMed, Web of Science, SciFinder, Google Scholar, Chinese National Knowledge Infrastructure database, and summarized it reasonably.
Result and Conclusion: The bioavailability of quercetin can be improved through the application of delivery systems technologies, such as microparticle delivery systems, solid dispersions, encapsulation, phospholipid complexes, and hydrogels. Quercetin delivery systems have been demonstrated to exhibit stronger antibacterial, anti-oxidant, anti-inflammatory, anti-cancer, and other pharmacological effects in vitro and in vivo animal experiments, promoting the development and optimization of quercetin delivery systems for clinical applications.
Quercetin, nanoparticles delivery systems, solid dispersions, phospholipid complexes, hydrogels, flavonoid.