Arun Narota, Gayatri Puri, Vikram P. Singh, Ashwani Kumar and Amarjit S. Naura* Pages 312 - 324 ( 13 )
A novel coronavirus SARS-CoV-2, which initially originated in China, has outstretched to all nations and turned out to be an intense global concern for both the governments and the public. In addition to the health concerns, the COVID-19 pandemic has caused a tremendous impact on the economic and political conditions of every nation. Ever since the start of the pandemic, the physicians were constrained to rely on the management strategies due to a lack of clear understanding of the disease pathogenesis caused by SARS-CoV-2 infection. Scientists are working tirelessly to gather maximum information about the deadly virus and come up with various strategies, which can be used against COVID-19 infection in terms of therapeutics and vaccine development. It is quite evident that the virus infection leads to acute respiratory distress syndrome (ARDS), and most of the deaths occur due to respiratory failure. As the virus spreads through respiratory droplets, the strenuous exercise of preventive measures and diagnosis at a large scale has been in practice across the globe to prevent transmission. This review amalgamates the various updates and acts as an umbrella to provide insights on SARS-CoV-2 mediated ARDS pathogenesis, the impact of co-morbidities, diagnostics, current progress in vaccine development, and promising therapeutics and immuno-modulatory strategies, highlighting various concerns and gaps that need to be addressed to fight current and future pandemics effectively.
COVID-19, SARS-CoV-2, Pandemic, ARDS, Treatment, Prevention.
Department of Biochemistry, Panjab University, Chandigarh-160014, Department of Biochemistry, Panjab University, Chandigarh-160014, Department of Cardiothoracic Vascular Surgery, Dayanand Medical College & Hospital, Ludhiana, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, Department of Biochemistry, Panjab University, Chandigarh-160014