Lei Zhang, Han Yu, Qiufen Tu, Qianjun He* and Nan Huang* Pages 636 - 649 ( 14 )
Hydrogen therapy has recently received increasing attention as an emerging and promising therapeutic technology due to its selective antioxidant property and cell energy regulatory capability in vivo. To solve the low solubility issue of hydrogen, a variety of nanomaterials and devices for hydrogen supply have recently been developed, aiming to increase the concentration of hydrogen in the specific disease site and realize controlled hydrogen release and combined treatment. In this review, we mainly focus on the latest advances in using hydrogen-generating devices and nanomaterials for hydrogen therapy. These developments include sustained release of H2, controlled release of H2, versatile modalities of synergistic therapy, etc. Also, bio-safety issues and challenges are discussed to further promote the clinical applications of hydrogen therapy and the development of hydrogen medicine.
Hydrogen medicine, anti-inflammation, nanomaterials, devices, anti-oxidation, COVID-19.
School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu