Mini-Review Article

Fluorescent Pyrazole Derivatives: An Attractive Scaffold for Biological Imaging Applications

Author(s):

Alexis Tigreros and Jaime Portilla*   Pages 197 - 206 ( 10 )

Abstract:

Among the huge number of fluorescent compounds described recently, pyrazole derivatives could play a paramount role in the design of probes for bioimaging applications–an important and simple tool for modern biology because of their easy synthetic methodologies, remarkable optical properties and chelating points. In this mini-review, we highlighted some pyrazole derivatives that have shown remarkable performance in this area; from the detection of chromium (III) with limits of detection of 37 × 10_-12 M to sensing glutathione in biological samples, as well as small molecule labeling of drugs and identifying unhealthy cells such as HeLa and labeling subcellular organelles. Evidently, this important class of N-heterocyclic compounds is part of interesting applications.

Keywords:

Drugs labeling, fluorescent bioimages, fused heterocycles, Glutathione detection, metal ion and biomolecules sensing,pyrazole-complexes, pyrazole derivatives.

Affiliation:

Department of Chemistry, Faculty of Sciences, Universidad de Los Andes, Bogota D.C, Department of Chemistry, Faculty of sciences, Universidad de Los Andes, Bogota D.C

Graphical Abstract:

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