Ludmila Filaretova, Tatiana Podvigina, Tatiana Bagaeva and Olga Morozova Pages 1045 - 1050 ( 6 )
Glucocorticoids may have dual action on the gastric mucosa: gastroprotective and ulcerogenic. In this article, we review the data which suggested that an initial action of endogenous glucocorticoids, including stress-produced ones as well as exogenous glucocorticoids is gastroprotective and consider possible mechanisms of the conversion of physiological gastroprotective action of glucocorticoid hormones to their pathological ulcerogenic effect.
The hypothalamic-pituitary-adrenocortical axis, glucocorticoids, dexamethasone, gastric mucosa, stress, indomethacin, injury, gastroprotection.
Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg 199034, Russia.