Ahmed A. Gahlan, Ahmed M. Haredy*, Sayed M. Derayea, Mahmoud A. Omar and Gamal A. Saleh Pages 2415 - 2424 ( 10 )
Aim: The present work provides a fast, simple, accurate, and inexpensive analytical method for the determination of Linagliptin (anti-diabetic drug).
Methods: The analysis was performed using a square wave adsorptive anodic stripping voltammetric technique (SWAASV) and glassy carbon electrode (GCE) as a working electrode. The experimental and instrumental parameters were studied and discussed to ensure the validity of the method.
Results: The method has a very good linearity (R2 = 0.9984), wide concentration range (0.189 - 2.268 μg mL-1), low detection limit of 0.052 μg mL-1 and low quantitation limit of 0.172 μg mL-1.
Conclusion: Linagliptin was identified successfully using the proposed method in pharmaceutical formulations, spiked human urine and plasma with 99.67, 91.96, and 92.78% recovery, respectively, and the results obtained were compared with other reported methods.
Linagliptin, glassy carbon electrode, Square wave voltammetry, Pharmaceutical, pure form, biological fluids.
Chemistry Department, Faculty of Science, Al-Azhar University, Assiut Branch, Assiut, Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut