Ankita Sood, Bimlesh Kumar*, Sachin Kumar Singh, Pankaj Prashar, Anamika Gautam, Monica Gulati, Narendra Kumar Pandey, Indu Melkani, Ankit Awasthi, Subhini A Saraf, Giovani Vidari, Mehmet Ozdemir, Faiq Hama Saeed Hussain, Esra Tariq Anwar, Muath Sheet Mohammed Ameen, Saurabh Gupta and Omji Porwal Pages 5468 - 5487 ( 20 )
Flavonoids are secondary metabolites that are widely distributed in plants. These phenolic compounds are classified into various subgroups based on their structures: flavones, flavonols, isoflavones, flavanones, and anthocyanins. They are known to perform various pharmacological actions like antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic and antiallergic, etc. Diabetes is a chronic progressive metabolic disorder that affects several biochemical pathways and leads to secondary complications such as neuropathy, retinopathy, nephropathy, and cardiomyopathy. Among them, the management of diabetic neuropathy is one of the major challenges for physicians as well as the pharmaceutical industries. Naturally occurring flavonoids are extensively used for the treatment of diabetes and its related complications due to their antioxidant properties. Moreover, flavonoids inhibit various pathways that are involved in the progression of diabetic neuropathy like the reduction of oxidative stress, decrease in glycogenolysis, increase glucose utilization, decrease in the formation of advanced glycation end products, and inhibition of the α-glucosidase enzyme. This review entails current updates on the therapeutic perspectives of flavonoids in the treatment of neuropathic pain. This manuscript explains the pathological aspects of neuropathic pain, the chemistry of flavonoids, and their application in amelioration of neuropathic pain through preclinical studies either alone or in combination with other therapeutic agents.
Flavonoids, diabetic neuropathy, oxidative stress, glycogenolysis, α-glucosidase, cardiomyopathy.
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, Department of Pharmaceutical Sciences, School of Bioscience and Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh 226025, Department of Chemistry, University of Pavia, 27100 Pavia, Department of Densitry, Tishk International University- Erbil, Kurdistan Region, Department of Medical Analysis, Tishk International University-Erbil, KRG, Department of Pharmacy, Tishk International University-Erbil, Kurdistan Region, Department of Pharmacy, Tishk International University-Erbil, Kurdistan Region, Department of Pharmacology, Chitkara University, Rajpura, Punjab, Department of Pharmacy, Tishk International University-Erbil, Kurdistan Region