Desu N.K. Reddy*, Fu-Yung Huang*, Shao-Pin Wang and Ramya Kumar Pages 5021 - 5029 ( 9 )
Background: Recent studies have focused on the nanoformulations of curcumin to enhance its solubility and bioavailability. The medicinal properties of curcumin-C3 complex, which is a combination of three curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) is less explored.
Objective: The aim of this study was to prepare curcumin-C3 encapsulated in chitosan nanoparticles, characterize and evaluate their antioxidant and antibacterial potential.
Methods: Ionic gelation method was used to prepare curcumin-C3 nanoparticles and was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy and nanoparticle tracking analysis. In vitro assays were performed to assess drug release, antioxidant and antibacterial activities.
Results: Curcumin-C3-chitosan nanoparticle showed an increased entrapment efficiency of >90%, drug release and improved antioxidant potential. Moreover, curcumin-C3-chitosan nanoparticle showed stronger inhibition of Escherichia coli and Staphylococcus aureus.
Conclusion: Chitosan is a suitable carrier for curcumin-C3 nanoparticle and can be used as a drug delivery system in the treatment of inflammatory and bacterial diseases.
Curcumin-C3, curcumin, chitosan, nanoparticle, antioxidant, E. coli, S. aureus.
Department of Chemistry, College of Sciences, National Cheng Kung University, Tainan, Department of Chemistry, College of Sciences, National Cheng Kung University, Tainan, Department of Chemistry, College of Sciences, National Cheng Kung University, Tainan, Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan