Rafaella M. Barros, Maísa S. de Oliveira, Kammila M. N. Costa, Mariana R. Sato, Karen L. M. Santos, Bolívar P. G. de L. Damasceno, Teresa Cuberes and Joáo A. Oshiro-Junior* Pages 4163 - 4173 ( 11 )
The encapsulation of bioactive compounds is an emerging technique for finding new medicines since it provides protection against ambient degradation factors before reaching the target site. Nanotechnology provides new methods for encapsulating bioactive compounds and for drug carrier development. Nanocarriers satisfactorily impact the absorption, distribution, metabolism, and excretion rate when compared to conventional carriers. The nanocarrier material needs to be compatible and bind to the drug and be bio-resorbable. In this context, the physicochemical characterization of encapsulated bioactive compounds is fundamental to guarantee the quality, reproducibility, and safety of the final pharmaceutical product. In this review, we present the physicochemical techniques most used today by researchers to characterize bioactive compounds in nanocarriers and the main information provided by each technique, such as morphology, size, degree of crystallinity, long-term stability, the efficacy of drug encapsulation, and the amount released as a function of time.
Biological activity, isolated compounds, nanoparticles, nanotechnology, ambient degradation, bioactive compounds.
Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Estadual da Paraiba, Av. das Baraunas, 351, Campina Grande, PB, 58109-753, Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Estadual da Paraiba, Av. das Baraunas, 351, Campina Grande, PB, 58109-753, Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Estadual da Paraiba, Av. das Baraunas, 351, Campina Grande, PB, 58109-753, Faculdade de Ciencias Farmaceuticas, Universidade Estadual Paulista (UNESP), Araraquara-Jau, Km 1, Araraquara, Sao Paulo, Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Estadual da Paraiba, Av. das Baraunas, 351, Campina Grande, PB, 58109-753, Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Estadual da Paraiba, Av. das Baraunas, 351, Campina Grande, PB, 58109-753, Laboratorio de Nanotecnologia, Universidad de Castilla-La Mancha (UCLM), Plaza Manuel Meca 1, 13400 Almaden, Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Estadual da Paraiba, Av. das Baraunas, 351, Campina Grande, PB, 58109-753