Ajay G. Namdeo, Sai H.S. Boddu, Haneen Amawi, Charles R. Ashby Jr., Diwakar B. Tukaramrao, Piyush Trivedi, R. Jayachandra Babu and Amit K. Tiwari* Pages 1712 - 1728 ( 17 )
Flavonoids are low molecular weight, polyphenolic phytochemicals, obtained from secondary metabolism of various plant compounds. They have a spectrum of pharmacological efficacies, including potential anticancer efficacy. Natural flavonoids are present in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine. Flavonoids can attenuate or inhibit the initiation, promotion and progression of cancer by modulating various enzymes and receptors in diverse pathways that involve cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis and metastasis. Furthermore, in vitro, flavonoids have been shown to reverse multidrug resistance when used as chemo-adjuvants. Flavonoids (both natural and synthetic analogues) interact with several oncogenic targets through dependent and independent mechanisms to mediate their anticancer efficacy in different types of cancer cells.
Flavonoids, secondary metabolism, anti-cancer therapies, multi-targeted agents, drug resistance, cancer cells.
Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, College of Pharmacy and Health Sciences, Ajman University, Ajman, Department of Pharmacy practice, Faculty of Pharmacy, Yarmouk University, P.O. BOX 566, Irbid 21163, Department of Pharmaceutical Sciences, St. John’s University, Queens, NY 11439, Department of Pharmacology and Experimental Therapeutics, The University of Toledo, Toledo, OH 43606, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, Department of Drug Discovery and Development, Auburn University, Auburn, AL 36849, Department of Pharmacology and Experimental Therapeutics, The University of Toledo, Toledo, OH 43606