Mohamed Adil A.A., Shabnam Ameenudeen, Ashok Kumar, S. Hemalatha, Neesar Ahmed, Nemat Ali, Abdullah F. AlAsmari, Mohammad Aashique and Mohammad Waseem* Pages 485 - 491 ( 7 )
Mitochondria are the crucial regulators for the major source of ATP for different cellular events. Due to damage episodes, mitochondria have been established for a plethora ofalarming signals of stress that lead to cellular deterioration, thereby causing programmed cell death. Defects in mitochondria play a key role in arbitrating pathophysiological machinery with recent evince delineating a constructive role in mitophagy mediated mitochondrial injury. Mitophagy has been known for the eradication of damaged mitochondria via the autophagy process. Mitophagy has been investigated as an evolutionarily conserved mechanism for mitochondrial quality control and homeostasis. Impaired mitophagy has been critically linked with the pathogenesis of inflammatory diseases. Nevertheless, the exact mechanism is not quite revealed, and it is still debatable. The purpose of this review was to investigate the possible role of mitophagy and its associated mechanism in inflammation-mediated diseases at both the cellular and molecular levels.
Mitochondria, Mitophagy, Oxidative Stress, Inflammation, Energy Homeostasis, Inflammasomes.
School of Life Sciences, BS Abdur Rahman Crescent Institute of Science & Technology, Chennai, School of Life Sciences, BS Abdur Rahman Crescent Institute of Science & Technology, Chennai, School of Life Sciences, BS Abdur Rahman Crescent Institute of Science & Technology, Chennai, School of Life Sciences, BS Abdur Rahman Crescent Institute of Science & Technology, Chennai, School of Life Sciences, BS Abdur Rahman Crescent Institute of Science & Technology, Chennai, Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, School of Life Sciences, BS Abdur Rahman Crescent Institute of Science & Technology, Chennai, School of Life Sciences, BS Abdur Rahman Crescent Institute of Science & Technology, Chennai