Alicia Beatriz Motta* Pages 6727 - 6743 ( 17 )
Polycystic Ovary Syndrome (PCOS) is a common endocrine and metabolic disorder that affects women in their reproductive age. Recent studies have shown that genes have an important role in the etiology of PCOS. However, the precise way in which these genes are transcriptionally and post-transcriptionally regulated is poorly understood.
The aim of the present review is to provide updated information on miRNAs and DNA methylation as epigenetic marks of PCOS.
The data presented here allow concluding that both microRNAs and DNA methylation can be considered as possible useful biomarkers when choosing the treatment for a specific PCOS phenotype and thus represent two important tools for the diagnosis and treatment of PCOS patients.
Polycystic ovary syndrome, epigenetic marks, miRNAs, DNA methylation, PCOS phenotypes, PCOS treatment.
Laboratorio de Fisio-patologia Ovarica, Centro de Estudios Farmacologicos y Botanicos (CEFYBO), Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Paraguay 2155, CP1121, Ciudad Autonoma de Buenos Aires