Julio Cezar de Almeida Junior, Edward Helal-Neto, Suyene R. Pinto, Sofia Nascimento Dos Santos, Emerson S. Bernardes, Mohammed Al-Qahtani, Fiammetta Nigro, Luciana M.R. Alencar, Eduardo Ricci-Junior and Ralph Santos-Oliveira* Pages 3282 - 3288 ( 7 )
Background: Adenocarcinoma of colon and rectum are one of the most common cancers worldwide, responsible for over 1,300,000 people diagnosed. Also, they are responsible for metastasis, which leads to death in less than 5 years.
Methods: In this study, we developed, characterized, and pre-clinically tested a new nano-radiopharmaceutical for early and differential detection of adenocarcinoma of colon and rectum.
Results and Conclusion: Results demonstrated the specificity of the developed nanosystem and the ability to reach the tumor with very specific targeting. Also, the imaging data support the use of this nano-agent as a nanoimaging- guided-radiopharmaceutical.
Polymeric nanoparticles, adenocarcinoma, cancer, imaging, nano-radiopharmaceutical, radiopharmacy.
Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro, Rio de Janeiro Federal University, Faculty of Pharmacy, Rio de Janeiro, King Faisal Specialist Hospital and Research Centre, Cyclotron and Radiopharmaceuticals Department, Riyadh, Federal University of Maranhao, Department of Physics, Sao Luis, Maranhao, King Faisal Specialist Hospital and Research Centre, Cyclotron and Radiopharmaceuticals Department, Riyadh, Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro