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General Review Article

Wogonin Alleviates Hyperglycemia Through Increased Glucose Entry into Cells Via AKT/GLUT4 Pathway

[ Vol. 25 , Issue. 23 ]


Shahzad Khan* and Mohammad A. Kamal   Pages 2602 - 2606 ( 5 )


Insulin resistance and type 2 Diabetes mellitus resulting in chronic hyperglycemia is a major health problem in the modern world. Many drugs have been tested to control hyperglycemia which is believed to be the main factor behind many of the diabetes-related late-term complications. Wogonin is a famous herbal medicine which has been shown to be effective in controlling diabetes and its complications. In our previous work, we showed that wogonin is beneficial in many ways in controlling diabetic cardiomyopathy. In this review, we mainly explained wogonin anti-hyperglycemic property through AKT/GLUT4 pathway. Here we briefly discussed that wogonin increases Glut4 trafficking to plasma membrane which allows increased entry of glucose and thus alleviates hyperglycemia.

Conclusion: Wogonin can be used as an anti-diabetic and anti-hyperglycemic drug and works via AKT/GLUT4 pathway.


Insulin, Glut4, AKT, hyperglycemia, diabetes mellitus, anti-diabetic.


Department of Pathophysiology, Wuhan University School of Medicine, Hubei, Wuhan, King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589

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