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Chronic Lymphocytic Leukemia Therapy: Beyond Chemoimmunotherapy

[ Vol. 18 , Issue. 23 ]

Author(s):

Julio Delgado, Tycho Baumann, Gabriela Ghita and Emili Montserrat   Pages 3356 - 3362 ( 7 )

Abstract:


Chemoimmunotherapy is the new gold standard of therapy for patients with advanced chronic lymphocytic leukemia (CLL). However, in spite of the high complete response rate achieved with chemoimmunotherapy, all patients eventually relapse and CLL is still incurable. Newer and more rationally developed compounds are clearly needed for these patients, in particular those with refractory disease. Among these agents, novel monoclonal antibodies, cyclin-dependent kinase inhibitors, chromokine receptor antagonists, lenalidomide, signal transduction inhibitors and pro-apoptotic molecules have recently shown some efficacy in patients with relapsed or refractory disease. Hopefully, the combined use of these agents in risk-adapted treatment strategies will improve the outcome of patients with CLL and set the stage for their cure.

Keywords:

Chronic lymphocytic leukemia, monoclonal antibodies, microenvironment, chemoimmunotherapy, cyclin-dependent kinase inhibitors, chromokine receptor antagonists, lenalidomide, signal transduction inhibitors, pro-apoptotic molecules, B-cell clone

Affiliation:

Institute of Hematology and Oncology, Department of Hematology, Hospital Clinic, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain.



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