Vijay Mishra, Nishika Yadav, Gaurav K. Saraogi , Murtaza M. Tambuwala and Namita Giri* Pages 2569 - 2583 ( 15 )
Diabetes has turned out to be one of the biggest worldwide health and economic burdens, with its expanded predominance and high complexity proportion. The quantity of diabetic patients is expanding enormously around the world. Several reports have demonstrated the sharp increment in the sufferers. Stable and acceptable blood glucose control is fundamental to diminish diabetes-related complications. Consequently, ceaseless endeavors have been made in antidiabetic drugs, treatment strategies, and nanotechnology based products to accomplish better diabetes control. The nanocarriers pertaining hypoglycaemics provide improved diabetes management with minimum risk of associated side effects. Dendrimers have caught an incredible attention in the field of drug delivery and personalized medicines. Dendrimers are three-dimensional well-defined homogenous nanosized structures consisting tree-like branches. The present review highlights the different aspects of dendrimers including fabrication, surface engineering, toxicological profile as well as delivery of antidiabetic drugs for the effective cure of diabetes.
Diabetes, dendrimer, drug delivery, toxicity, nanocarrier, toxicological profile.
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, School of Pharmacy and Technology Management, SVKM's NMIMS, Shirpur, SAAD Centre for Pharmacy and Diabetes, School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, BT52 1SA, Northern Ireland, School of Pharmacy, Ferris State University, Big Rapids, Michigan MI4930, MA