Xavier-Ravi Baskaran, Antony-Varuvel G. Vigila, Kilimas Rajan, Shouzhou Zhang and Wenbo Liao* Pages 2677 - 2693 ( 17 )
Background: Nanopharmaceuticals have rapidly emerged as a means to cure several diseases. There are numerous reports describing the development and application of nanopharmaceuticals. Here, we discussed nanoparticle synthesis and the mechanisms to scavenge free radicals. We also discuss their major properties and list several commercially available nanomedicines.
Results: Reactive oxygen and hydrogen species are formed during normal metabolism, and excessive reactive species can damage proteins, lipids, and DNA and cause disease. Plant- and microbe-based nanoparticles, which can protect tissues from free radical damage, have recently gained research momentum because they are inexpensive and safe.
Conclusion: Synthetic and biocompatible nanoparticles exhibit antioxidant, antidiabetic, anti-inflammatory, and anticancer properties, which can be used to treat several diseases. Further studies are needed to investigate their sizes, dose-dependent activities, and mechanisms of action.
Antioxidant, anticancer, DPPH, free radicals, reactive oxygen species, silver nanoparticles
State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510 275, Department of Zoology, St. Xavier's College, Palayamkottai 627 002, Tamil Nadu, Department of Botany, St. Joseph's College, Tiruchirappalli 620 002, Tamil Nadu, Shenzhen Key Laboratory of Southern Subtropical Plant Diversity, Fairy Lake Botanical Garden, Shenzhen & Chinese Academy of Sciences, Shenzhen 518 004, State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510 275