Harry Robberecht*, Tess De Bruyne, Elisabeth Davioud-Charvet, John Mackrill and Nina Hermans Pages 1694 - 1706 ( 13 )
Background: Selenium (Se) is a trace element active in selenoproteins, which can regulate oxidative stress. It is generally perceived as an import factor for maintaining health in the elderly.
Methods: The goal of this review is to discuss selenium concentration in biological samples, primarily serum or plasma, as a function of age and its relation with longevity. The elemental level in various age-related diseases is reviewed.
Conclusion: Highest selenium values were observed in healthy adults, while in an elderly population significantly lower concentrations were reported. Variables responsible for contradictory findings are mentioned. Risk and benefits of Se-supplementation still remain under debate.
Selenium, biological materials, longevity, age-related diseases, oxidative stress, Se-supplementation.
Research Group NatuRA, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Research Group NatuRA, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Laboratoire d'Innovation Moleculaire et Application (LIMA), UMR7042 CNRSUnistra- UHA, European School of Chemistry, Polymers and Materials (ECPM), 25, rue Becquerel, F-67087 Strasbourg, Department of Physiology, School of Medicine, University College Cork, Western Gateway Building, Western Road, Cork, T12XF62, Research Group NatuRA, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp