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Review Article

Sulfated Polysaccharides from Macroalgae for Bone Tissue Regeneration

[ Vol. 25 , Issue. 11 ]


Jayachandran Venkatesan*, Sukumaran Anil, Sneha Rao, Ira Bhatnagar and Se-Kwon Kim   Pages 1200 - 1209 ( 10 )


Background: Utilization of macroalgae has gained much attention in the field of pharmaceuticals, nutraceuticals, food and bioenergy. Macroalgae has been widely consumed in Asian countries as food from ancient days and proved that it has potential bioactive compounds which are responsible for its nutritional properties. Macroalgae consists of a diverse range of bioactive compounds including proteins, lipids, pigments, polysaccharides, etc. Polysaccharides from macroalgae have been utilized in food industries as gelling agents and drug excipients in the pharmaceutical industries owing to their biocompatibility and gel forming properties. Exploration of macroalgae derived sulfated polysaccharides in biomedical applications is increasing recently.

Methods: In the current review, we have provided information of three different sulfated polysaccharides such as carrageenan, fucoidan and ulvan and their isolation procedure (enzymatic precipitation, microwave assisted method, and enzymatic hydrolysis method), structural details, and their biomedical applications exclusively for bone tissue repair and regeneration.

Results: From the scientific results on sulfated polysaccharides from macroalgae, we conclude that sulfated polysaccharides have exceptional properties in terms of hydrogel-forming ability, scaffold formation, and mimicking the extracellular matrix, increasing alkaline phosphatase activity, enhancement of biomineralization ability and stem cell differentiation for bone tissue regeneration.

Conclusion: Overall, sulfated polysaccharides from macroalgae may be promising biomaterials in bone tissue repair and regeneration.


Sulfated polysaccharides, fucoidan, carrageenan, ulvan, bone tissue engineering, macroalgae.


Yenepoya Research Center, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka, 575018, Department of Dentistry, Hamad Medical Corporation, PO box 3050, Doha, Yenepoya Research Center, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka, 575018, CSIR-Center for Cellular and Molecular Biology, Clinical Research Facility, Medical Biotechnology Complex, Uppal Road, Hyderabad, Telangana, 500007, Department of Marine Life Sciences, Korean Maritime and Ocean University, 727 Taejong-ro, Yeongdo-Gu, Busan 49112

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