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Review Article

The Regulatory Roles of Long Non-Coding RNA in the Chemoresistance Process of Ovarian cancer

[ Vol. 25 , Issue. 8 ]


Jiayuan Qu, Mohammad Amjad Kamal and Chengfu Yuan*   Pages 856 - 861 ( 6 )


Background: Ovarian cancer is the most malignant tumor in gynecological tumors, with low five-year survival rate. The main reasons are diagnosis at advanced stages (the early symptoms are uncharacteristic, and most are diagnosedlate.), relapse, and resistance to existing chemotherapy drugs.

Methods: Search strategy was performed in the following steps. Firstly, LncRNA related to ovarian cancer was retrieved by using the LncRNA Disease database, and articles were searched by searching keywords: ovarian cancer, drug resistance, and LncRNA retrieved from the LncRNA Disease database.

Results/Conclusion: With the development of the study on drug resistance of ovarian cancer, the role of LncRNAs as sensitive biomarker and therapeutic target has emerged, providing a direction for precision medicine of ovarian cancer resistance.


Ovarian cancer, chemoresistance, long non-coding RNA, LncRNA, drug resistance, gynecological tumors.


Department of Biochemistry, China Three Gorges University, Yichang 443002, King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah, 21589, Department of Biochemistry, China Three Gorges University, Yichang 443002

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