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Heparin - a Key Drug in the Treatment of the Circulatory Degenerative Diseases: Controlling its Action with Polymers

[ Vol. 18 , Issue. 18 ]

Author(s):

Krzysztof Szczubialka, Kamil Kaminski, Katarzyna Zasada, Anna Karewicz and Maria Nowakowska   Pages 2591 - 2606 ( 16 )

Abstract:


The properties of heparin, a key anticoagulant, are reviewed. The important issues in heparinotherapy, i.e., reaching quick anticoagulant effect, maintaining therapeutic level of anticoagulation, heparin inhibition and non-invasive heparin formulations have been reviewed and discussed, with the focus on the role of polymeric substances in the proposed solutions.

Keywords:

Heparin, anticoagulation, unfractionated heparin, low molecular weight heparin, heparin reversal, noninvasive delivery, heparinotherapy, heparin inhibition, polymeric substances, glycosaminoglycans (GAGs)

Affiliation:

Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.



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