Pablo Ahumada-Pascual, Daniel G. Gañán, Yasmina E.B. Montero and Ana Velasco* Pages 376 - 380 ( 5 )
Multiple sclerosis is a high-frequency neurological disorder in young adults. Although there are some genetic and environmental factors that have been related to the onset of the disease, these are still not completely understood and nowadays multiple sclerosis can neither be prevented, nor its symptom effectively treated due to disease heterogeneity. For this reason, the search of prognostic factors and new therapeutic compounds for MS has long aroused among clinicians and researchers. Among these therapeutic compounds, GEMSP, which consists of a mixture of functional constituents as fatty acids, antioxidants, free radical scavengers and amino acids linked individually to poly-L-Lysine (PL), is emerging as a promising drug for MS treatment. Pre-clinical studies using GEMSP have demonstrated that this drug strongly inhibits brain leukocyte infiltration and completely abolishes experimental autoimmune encephalomyelitis. In addition, in an open clinical trial in humans treated with GEMSP, in 72% of the cases, a positive evolution of the state of the MS patients treated with GMSP was observed. In this review a biochemical characterization of main constituents of GEMSP, which include fatty acids as oleic acid, linoleic acid or azelaic acid and the antioxidants alpha-tocopherol or ascorbic acid, will be provided in order to understand their proved therapeutic effects in MS.
Multiple sclerosis, GEMSP, fatty acids and antioxidants, neurological disorder, fatty acid.
Departamento de Bioquimica y Biologia Molecular. Instituto de Neurociencias de Castilla y Leon (INCYL). Universidad de Salamanca. Instituto de Investigacion Biomedica de Salamanca (IBSAL), Olive Nutricion Clinica. Salamanca, Servicio de Neurologia del Complejo Asistencial Universitario de Salamanca (CAUSA). Instituto de Investigacion Biomedica de Salamanca (IBSAL), Departamento de Bioquimica y Biologia Molecular. Instituto de Neurociencias de Castilla y Leon (INCYL). Universidad de Salamanca. Instituto de Investigacion Biomedica de Salamanca (IBSAL)