Anna W. Sobanska* and Elzbieta Brzezinska Pages 6784 - 6794 ( 11 )
A review of applications of the Immobilized Artificial Membrane (IAM) chromatography in drug discovery is given. IAM chromatography is presented as a tool to predict the interactions of solutes with biomembranes, blood-brain barrier permeability, volume of distribution, oral and skin absorption of drugs and compared to other in vitro techniques used to study drug bioavailability (caco-2 cells, liposome partition). Unbound phosphatidylcholine based stationary phases are also discussed. Some new trends and ideas in the IAM chromatography are presented.
IAM chromatography, blood-brain barrier, skin permeability, oral bioavailability.
Department of Analytical Chemistry, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Department of Analytical Chemistry, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz