I. Gouni-Berthold and A. Sachinidis Pages 1261 - 1271 ( 11 )
Various growth factors such as the platelet derived growth factor (PDGF), insulin-like growth factor (IGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF) transduce their mitogenic signals through the activation of tyrosine kinase receptors (RTKs). Since enhanced RTK activity has been associated with the development of proliferative diseases such as atherosclerosis and cancer, there has been an increased interest recently in the development of small molecule RTK inhibitors for the prevention / treatment of the aforementioned diseases. Many cell culture and animal studies have shown that catechins, the main compounds of the green tea leaves, are potent natural inhibitors of several RTKs. In the present article we review the various molecular and cellular mechanisms through which catechins inhibit the growth factor-RTK-mediated signal transduction pathways and exert their antiproliferative / apoptotic effects.
catechins,tyrosine receptor kinases,growth factors,cancer,atherosclerosis
, University of Cologne, Center of Physiology and Pathophysiology, Robert-Koch-Str. 39, 50931 Cologne,Germany.