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Non-Canonical Peptides Bound to MHC

[ Vol. 15 , Issue. 28 ]

Author(s):

Stephanie L. Day, Paul A. Ramsland and Vasso Apostolopoulos   Pages 3274 - 3282 ( 9 )

Abstract:


Central to the initiation of a T cell dependent immune response is the recognition of major histocompatibility complex (MHC) class I or class II molecules (in humans termed HLA and in mice termed H-2) bound to antigenic peptide. T cell receptors (TCR) have programmed specificity for particular peptide/MHC complexes, which ensures focused immune responses are generated against the antigen source. To design effective peptide based vaccines a comprehensive understanding of the specific interactions between MHC molecules and peptide, and of TCR recognition of MHC/peptide is valuable. We place particular emphasis on non-canonical bound peptides and their use in immunotherapy studies.

Keywords:

Non-canonical peptides, MHC class I, vaccine

Affiliation:

Macfarlane Burnet Institute for Medical Research, Centre for Immunology, Immunology and Vaccine Laboratory, AMREP, 85 Commercial Road, VIC, Australia.



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