Submit Manuscript  

Article Details

Myelination in Bipolar Patients and the Effects of Mood Stabilizers on Brain Anatomy

[ Vol. 15 , Issue. 22 ]


Paolo Brambilla, Marcella Bellani, Ping-Hong Yeh and Jair C. Soares   Pages 2632 - 2636 ( 5 )


In this review, we debate the evidence for abnormal white matter microstructure and myelination in bipolar disorder, as mainly detected by diffusion tensor imaging (DTI) studies. The effects of mood stabilizers on white matter are discussed, based on available findings from human and animal studies. Last, perspectives in this field of research are also drawn.


Diffusion imaging, white matter, prefrontal cortex, hippocampus, amygdala, corpus callosum, lithium, valproate


Dipartimento di Patologia e Medicina Clinica e Sperimentale, Cattedra di Psichiatria, Policlinico Universitario, Via Colugna 50, 33100 Udine, Italy.

Read Full-Text article