Submit Manuscript  

Article Details


Chronic Graft-Versus-Host Disease

[ Vol. 14 , Issue. 20 ]

Author(s):

Javier Bolanos-Meade and Georgia B. Vogelsang   Pages 1974 - 1986 ( 13 )

Abstract:


Chronic graft-versus-host disease is the most common late, non-relapse complication of transplantation yet it is also one of the least studied. It is the primary cause of morbidity and mortality of long-term survivors of allogeneic bone marrow transplants. Like acute graft-versus-host disease, it does have a strong antitumor effect. The recent National Institutes of Health sponsored Chronic Graft-versus- Host Disease Consensus Conference has proposed new criteria for diagnosis and staging, pathology, biomarkers, response and supportive care. New understanding of the pathophysiology of chronic graft-versus-host disease (i.e. the role of B cells) is already having an impact on therapy. Novel agents such as pentostatin, mycophenolate mofetil, rituximab, extracorporeal photochemotherapy, etc. are improving the outcome of steroid refractory chronic graft-versus-host disease.

Keywords:

Host Disease, Chronic graft, antitumor effect, pathology, Novel agents, pentostatin, mycophenolate mofetil, extracorporeal photochemotherapy, rituximab

Affiliation:

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Bunting Blaustein Cancer Research Building 2M87, 1650 Orleans St., Baltimore, MD 21231, USA.



Read Full-Text article