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Chronic Graft-Versus-Host Disease

[ Vol. 14 , Issue. 20 ]


Javier Bolanos-Meade and Georgia B. Vogelsang   Pages 1974 - 1986 ( 13 )


Chronic graft-versus-host disease is the most common late, non-relapse complication of transplantation yet it is also one of the least studied. It is the primary cause of morbidity and mortality of long-term survivors of allogeneic bone marrow transplants. Like acute graft-versus-host disease, it does have a strong antitumor effect. The recent National Institutes of Health sponsored Chronic Graft-versus- Host Disease Consensus Conference has proposed new criteria for diagnosis and staging, pathology, biomarkers, response and supportive care. New understanding of the pathophysiology of chronic graft-versus-host disease (i.e. the role of B cells) is already having an impact on therapy. Novel agents such as pentostatin, mycophenolate mofetil, rituximab, extracorporeal photochemotherapy, etc. are improving the outcome of steroid refractory chronic graft-versus-host disease.


Host Disease, Chronic graft, antitumor effect, pathology, Novel agents, pentostatin, mycophenolate mofetil, extracorporeal photochemotherapy, rituximab


Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Bunting Blaustein Cancer Research Building 2M87, 1650 Orleans St., Baltimore, MD 21231, USA.

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