Dual Inhibition and Monitoring of Beta-Amyloid Fibrillation by a Luminescent Iridium(III) Complex

Author(s):

Chun-Yuen Wong, Lai-Hon Chung, Lihua Lu, Modi Wang, Bingyong He, Li-Juan Liu, Chung-Hang Leung and Dik-Lung Ma   Pages 439 - 444 ( 6 )

Abstract:

In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.

Keywords:

Amyloid, aggregation, Alzheimer's, luminescent probe, iridium.

Affiliation:

Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong, China.

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