Yong Du, Soomro Sanam, Krause Kate and Chandra Mohan Pages 2320 - 2349 ( 30 )
This article reviews the commonly used murine strains for studying lupus and lupus nephritis, including strains that develop lupus spontaneously, congenic strains, induced models of lupus, as well as genetically engineered mouse models of lupus bearing transgenes or knockouts. The review then summarizes the main cellular and molecular pathways that lead to the pathogenesis of this autoimmune disease, including autoantibodies. Finally, it concludes with therapeutic insights gained from using mouse models of lupus. To sum, much of what we have learned about lupus has arisen from studying mouse models of the disease, and the laboratory mouse continues to be one of the best tools for studying human SLE.
Lupus, animal models, nephritis, autoantibody, genetics.
, , , Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd, Room 2018, Houston, TX – 77204, USA.